- Player with the most assists in 21st century
- Player with the most assists in El Clásico
- Player with the most goals in one year (91 in 2012)
- Player with the most goals in La Liga (474)
- Player with the most goals for one club of all time (672)
- Player with the most goals in South American National Teams
- Player with the most goals in El Clásico (Real Madrid vs FC Barcelona)
- Player with the most goals for Argentina
- Player with the most goals for FC Barcelona (672)
- Player with the most goal involvements in one year (113 - 91G + 22A)
- Player with the most goal involvements in one season (115 - 82G + 33A)
- Player with the most goal involvements in 21st century
- Player with the most goal involvements in Copa America (28 - 13G + 15A)
- Player with the most consecutive games scoring goals in La Liga (21)
- Player with the most Player Of The Match awards in Copa America (13)
- Player with the most Player Of The Match awards in World Cups (11)
- Player with the most top goalscorer awards in top leagues (8)
- South American player with the most goals of all time
- Only player with 4 Player Of the Tournament awards with National Teams
- First athlete from a team sport to win the L'Equipe Champion des Champions twice
- First athlete from a team sport to win a Laureus award
- First soccer player and first athlete from outside the US to win the Sporting News Athlete of the Year
- Only player (with Di María) to win the 5 major tournaments with his team: U-20 World Cup, Olympic Gold, Copa América, Euro-American Cup and World Cup
- Included in Time 100, the list of The Most Influential People of 2011
- Included in Time 100, the list of The Most Influential People of 2012
- Included in Time 100, the list of The Most Influential People of 2023
| - Player with the most goals in history for clubs
- Player with the most goals in history for national teams
- Player with the most goals in history, according to FIFA
- Player with the most goals in Champions League
- Player with the most goals in Champions League knockout stages
- Player with the most goals in european club competitions (UEFA)
- Player with the most goals in UEFA Euro qualifiers
- Player with the most goals in UEFA Euro
- Player with the most goals for Portugal
- Player with the most goals for Real Madrid (451)
- Player with the most goals in one season in Champions League (17)
- FIFA The Best Special Award
- Included in Time 100, the list of The Most Influential People of 2014
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